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Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through inhibition of liver glucose production and an increase in muscle glucose.

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Metformin exposes to lactic acidosis by diminution of its renal clearance. Treatments with derivatives of metformin should be stopped for 48 hours following.This study suggests that metformin interacts with thyroid function, possibly by inhibiting peripheral thyroxine to triiodothyronine conversion.

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